realize the potential
of Metabolic Medicine
Metabolic Cancer Therapies
Put simply, cancer cells have aberrant energy metabolism compared to normal cells. Metabolic Cancer therapies attempt to exploit this difference. Cancer cells have a reduced capacity to generate energy with oxygen (oxidative energy production), with a concurrent increase in energy generation without oxygen. On Average a healthy cell produces 89% of its energy using oxygen, and 11% through non-oxidative metabolism (non-oxidative metabolism is also known as “fermentation”). Oxidative energy production is far more efficient than fermentation. Almost 20 times more energy is released when glucose is completely oxidized, as opposed to when it is fermented.
Healthy Mitochondria. Note the abundant looping structures inside the mitochondria (cristae), this is where all energy is produced through oxidative pathways.
Oxidative energy production takes place in a cellular organelle called the mitochondria. The mitochondria are known as the cellular “power plants.” Also telling is the fact that the greater the degree of fermentation displayed by a given cancer, the more aggressive the cancer. Because a tumor cell’s mitochondria appear to be dis-regulated, and generate energy by such an inefficient pathway, they have to consume much more glucose to remain viable. A glance at a PET scan, which uses a radioactive labeled glucose analog to image cancer, provides stunning visual evidence of the voracious appetite tumor cells have for glucose compared to normal tissue.
Altered Metabolism May be One of the Drivers of Cancer
It is well established that once a cell has an impaired ability to produce energy through oxidative pathways, the genomic instability (increased potential for DNA mutations to occur) that accompanies tumor development, inevitable follows. While it’s true that most of the agents known to cause cancer; chemical carcinogens, viruses, radiation, and inflammation can cause mutations to DNA, it is also true these provocative agents damage the mitochondria. The metabolic theory of cancer states that once the mitochondria of a given cell become disregulated, and the cell reverts to fermentation to obtain energy, a plethora of metabolic and epigenetic modifications participate in the origin of cancer.
Poly-MVA Research, Science and Studies
Energy and Ischemia Studies
Antonawich, 2004
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Sudheesh, 2009
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Sudheesh, 2010
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Ajith, et al. , Antonawich 2014
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Dr. Anderson Research and Protocols
Oncology Outcome Studies
Oncologist 1,000 Patient/Stage IV Study
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KGK Synergize
Lab Tests on Cell Lines
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Case studies for prostate
Shari Lieberman, Ph.D., C.N.S., F.A.C.N.,
and James W. Forsythe, M.D., H.M.D.
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Radio Therapy
Selim 2012 A
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Selim 2012 B
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El-Marakby 2013 A
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El-Marakby 2013 B
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Published Articles
Poly-MVA / Lipoic Acid Complex articles on Pubmed.com
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FQ-Tox-Antiox-LAMC-Case-2012
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Dr. Anderson Research and Protocols
Nutrient Injection Therapies for Chronic Fatigue and Fibromyalgia
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Poly-MVA Inventor
See List of Patent filings
for Dr. Merrill Garnett
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CLINICAL STUDIES Summary
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Safety LAMC Summary
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Dr. Merrill Garnett SCIENTIFIC RESEARCH
Electrogenetics Summary
The Equivalent Circuit Code of the Living State
2 ECS May 2009 Paramagnetic Doping of DNA Forms SpinLattice Films
Molecular Qi
The Unique Nature of Palladium in Therapeutic Research
Forsythe single sheet summary
Poly-MVA Articles
Poly MVA causes significant cell death after 48 Hours of exposure
per mL. SHAPE \* MERGEFORMAT CPM
The table below illustrates the statistically significant level of cell death
(p must be equal to or less than 0.05) induced by POLY-MVA after 48 hours of initial exposure:
Garnett McKeen In vitro Cancer Assays:
Garnett McKeen Laboratory Inc. (GML) chose to mimic the National Cancer Institute’s (NCI) cell screening protocol.
The following cell lines were selected from the NCI repository:
MCF-7 (breast adenocarcinoma), and A549 (lung non-small cell adenocarcinoma).
The data below represents the completion of the Breast Cancer (MCF-7), Ovarian Cancer (OVCAR-5) and Lung Carcinoma (A549) assay.
We have also completed assays using stage IV glioblastoma multiforme (H-80) and astrocytoma (H-4) brain tumor lines.
As noted below, all of the studies demonstrated significant cell death.
CANCER CELL DEATH RATE IN 5 CELL LINES
After 48 hours of exposure
